One of the determining factors for a successful research output is the design of the research itself. Thus, a researcher, a methodologist or an epidemiologist and a biostatistician may each have his/her own perspective of how to optimize the design of research, by playing an active role in both planning and conducting the research. Therefore, this e-book emphasizes the importance of the role of a biostatistician in managing and conducting research consultations mainly for research that revolves around the medical field. Successful biostatistics consultation requires a collection of technical and collaborative skills. The full spectrum of biostatistical consulting skills are rarely taught in training programs. However, by acquiring all the relevant skills for biostatistical consultation, one can continue to hone such skills by learning and gaining relevant experience throughout one’s career. The discussion is divided into five sections: Essential consulting skills for biostatisticians; Begins with an initial evaluation of the research proposal; Techniques to improve subject matter knowledge during consultation process; Tips to provide an optimal biostatistical consulting service; and Tips to enhance research consultation skills. The discussion is useful for both beginners and also for current professionals aiming to enhance their research consultation skills.